In this video, Jeffrey Kozlow, MD, demonstrates both sentinel lymph node biopsy and the primary resection with skin graft reconstruction of a plantar foot melanoma. The patient is a 59-year-old man who presents a 3.5 mm deep melanoma on his foot. First, sentinel lymph node biopsy from the inguinal region is demonstrated—including the use of lymphoscintigraphy and intra-operative lymph node mapping techniques, which utilize a gamma probe and blue dye. The second part of the operation demonstrates local excision of the primary lesion, followed by a full-thickness skin graft for reconstruction. With the increased incidence of melanoma, along with some of the unique locations of disease, such as the plantar foot, Dr. Kozlow discusses the role that plastic surgeons can have in the surgical management of melanoma. He discusses the importance of participating in institutional melanoma tumor boards and the benefits for plastic surgeons who want to be involved with oncologic care.