OasisLMS

This randomized controlled trial compares three-year outcomes after collagenase clostridium histolyticum injection and percutaneous needle fasciotomy for isolated metacarpophalangeal joint Dupuytren contracture. Both treatments produced similar initial improvement in extension deficit, but recurrence or disease progression occurred in 47% of patients treated with needle fasciotomy compared with 19% of collagenase-treated patients. Functional outcomes measured by Quick-DASH remained low and similar between groups at three years, and no serious adverse events were reported. These findings suggest that collagenase injection may provide greater durability than percutaneous needle fasciotomy for appropriately selected patients with isolated MCP joint contracture, although the results should not be generalized to PIP joint disease.

Intended Audience

This educational activity is intended for plastic surgery practitioners, residents, and other healthcare professionals interested in translating expanded knowledge into practice for the improvement of patient outcomes in plastic and reconstructive surgery.

Learning Objectives

After viewing this course, the participant should be able to:

1. Compare the three-year recurrence and progression of Dupuytren disease after collagenase injection versus percutaneous needle fasciotomy.
2. Describe the short-term correction of metacarpophalangeal joint contracture following the two treatment approaches.
3. Identify the criteria used to define treatment failure and recurrence in patients with isolated metacarpophalangeal joint contracture.
4. Apply the study findings when selecting treatment for patients with isolated metacarpophalangeal joint Dupuytren contracture.

Rasmus W. Jørgensen, MD, PhD

Claus H. Jensen, MD

Stig Jørring, MD

Editor-in-Chief: Kevin C. Chung, MD

Co-editor: Amy S. Colwell, MD

Justine S. Kim, MD

Kerri Woodberry, MD

• Systems-based Practice
• Medical Knowledge
• Practice-based Learning and Improvement

Accreditation

The American Society of Plastic Surgeons (ASPS) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation

The ASPS designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AMA PRA Category 1 Credit™: 1.0

Media: Journal Article

Release Date: 10/2/2026

Expiration Date: 10/2/2026*

Estimated time to complete this course: 1 hour

*Course access ends on course expiration date

Disclosure Policy

The American Society of Plastic Surgeons (ASPS) requires all instructors, planners, reviewers, managers and other individuals in a position to control or influence the content of an activity to disclose all relevant financial relationships or affiliations. All identified conflicts of interest must be resolved and the educational content thoroughly vetted by ASPS for fair balance, scientific objectivity and appropriateness of patient care recommendations. ASPS also requires faculty/authors to disclose when off-label/unapproved uses of product are discussed in a CME activity or included in related materials.

Disclaimer: All relevant financial relationships for planners, faculty and others in control of content (either individually or as a group) are reviewed by the ASPS Continuing Education Committee and have been mitigated, if applicable.

The following planners and faculty members have no relevant financial relationships or affiliations to disclose:

Rasmus W. Jørgensen, MD, PhD

Claus H. Jensen, MD                                                                                                                   

Stig Jørring, MD

Justine S. Kim, MD

Kerri Woodberry, MD

Recognition Statement

The Continuing Medical Education (CME) credits offered by this activity are enhanced by ASPS Learner Credit Reporting for learners who have opted into this reporting. Successful completion of this CME activity enables active American Board of Surgery (ABS) members the opportunity to earn credit toward the CME requirement of the ABS's Continuous Certification program when claimed within 30 days of completion of the activity.

Directly provided by the American Society of Plastic Surgeons® (ASPS®)

Participants in ASPS-accredited education who want their CME credits reported to certifying and state licensing boards must opt-in to reporting and add their NPI as well as state license ID and/or collaborating board ID(s) before claiming credit.