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Amniotic Band Syndrome: Head-to-Toe Manifestations ...
Journal CME Article: Amniotic Band Syndrome: Head- ...
Journal CME Article: Amniotic Band Syndrome: Head-to-Toe Manifestations and Clinical Management Guidelines Article
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Amniotic Band Syndrome (ABS) is a congenital condition that occurs in utero when fibrous amniotic bands constrict various parts of the fetal body, potentially leading to malformations, deformations, and even amputations. The etiology of ABS is often debated, with intrinsic theories pointing to genetic disruptions and extrinsic theories suggesting mechanical pressure from ruptured amniotic membranes as potential causes. ABS affects approximately 1 in 1,200 to 15,000 live births and some stillbirths, making it a relatively rare condition.<br /><br />Common manifestations include limb constrictions which can range from simple soft tissue indentations to complete limb amputations. Facial clefts and other craniofacial defects, as well as abdominal constriction, may also be present. The diagnosis is typically made postnatally based on physical observations, though prenatal ultrasounds can sometimes identify the condition when associated anatomical anomalies are evident.<br /><br />Management of ABS is largely surgical and often involves plastic surgeons. The timing and technique of surgical interventions depend on the severity and anatomical location of the manifestations. For limb complications, early surgical intervention may be necessary to address vascular or neurological compromise. Many cases can benefit from techniques such as circular or Z-plasty skin incisions to improve function and aesthetics. Recent trends favor single-stage over two-stage surgeries for constriction band release.<br /><br />In some cases, fetal surgery might be considered, particularly to release bands that threaten limb viability before birth. Emerging fetoscopic techniques allow for less invasive interventions, which could reduce long-term scarring and complications. These procedures are performed during the second trimester and are currently subject to ongoing research to optimize outcomes and minimize risks.<br /><br />Overall, treatment strategies for ABS require a highly personalized approach tailored to the individual patient's needs, addressing both immediate functional issues and long-term quality of life.
Keywords
Amniotic Band Syndrome
congenital condition
fetal malformations
limb amputations
prenatal diagnosis
surgical management
fetoscopic techniques
plastic surgery
constriction bands
personalized treatment
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